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Merikangas KR, Akiskal HS, Angst J, Greenberg PE, Hirschfeld RM, Petukhova M, et al

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PSD-95 was found to bind to NMDAR2B and intracellular neuronal nitric oxide synthase (nNOS) as part of a scaffold synaptic protein, and in the presence of intracellular calcium, PSD-95 plays a crucial role in the mechanism by which NMDAR activity triggers the production of nitric oxide production by nNOS and excitotoxicity (Cui et al., 2007